BETA-AMYLOID (1-28), N-TERMINAL UNLABELED
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS: 109770-29-8
Molecular Formula: C145 H209 N41 O46
BETA-AMYLOID (1-28), N-TERMINAL UNLABELED - Names and Identifiers
BETA-AMYLOID (1-28), N-TERMINAL UNLABELED - Physico-chemical Properties
| Molecular Formula | C145 H209 N41 O46 |
| Molar Mass | 3262.46 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Appearance | White lyophilized powder. |
| Storage Condition | −20°C |
| In vitro study | β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing. 4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. |
| In vivo study | β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu 2+ interaction. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K a 10 7 M -1 . |
BETA-AMYLOID (1-28), N-TERMINAL UNLABELED - Risk and Safety
| WGK Germany | 3 |
BETA-AMYLOID (1-28), N-TERMINAL UNLABELED - Reference Information
| biological activity | β-Amyloid (1-28) is a β-amyloid protein fragment that can participate in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brain of patients with Alzheimer's disease. |
| target | Amyloid-β |
| in vitro study | β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing 4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. |
| in vivo study | β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His, His, his in human fragments) to the Ab-Cu 2 interaction. copper binds to beta-amyloid (1-28) at pH 7.4 with an affinity of k a 10 7 m -1 . |
Last Update：2024-04-09 21:04:16
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